UNCLES has been succeeded by Clust, which is freely available as a straightforwardly installed and used package.

See Clust

UNCLES has two types: A and B. All current applications of UNCLES that I have performed have been using type A, which is identical to the Bi-CoPaM method. Read the description of the Bi-CoPaM method for that or read the journal article listed below.

Implementation is freely available in the R package ‘UNCLES‘.



Basel Abu-Jamous, Rui Fa, David J. Roberts, and Asoke K. Nandi. “UNCLES: Method for the identification of genes differentially consistently co-expressed in a specific subset of datasets”. BMC Bioinformatics, 2015, 16: 184, doi: 10.1186/s12859-015-0614-0. View online | Download PDF